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LabDisk

A multi-purpose, multi-target Point-of-Care diagnostic platform

Presentation:
Technology:

The LabDisk is a CD-shaped microfluidic cartridge that integrates in situ extraction, purification and amplification for fully-automated molecular-based (DNA, RNA) identification of pathogens. All (bio)chemical components are integrated (buffers, amplification reagents, primers). It is compatible with both PCR and isothermal amplification. Immunoassays with pre-stored reagents are also performed with the LabDisk.

Key Innovations:

  • Universality: Suitable for parasites, bacteria and viruses
  • Adaptability: Easy exchange of primer sets according to end-users’ needs, while keeping all other disk and biochemical components
  • Multiplexity: Up to 12 targets detectable in LAMP mode (geometric multiplexing). Up to 3 x 12 targets in PCR mode (additional color multiplexing)
  • Interoperability: Same device can handle DNA/RNA, protein and clinical chemistry cartridges
  • Scalable fabrication technology: From prototyping to batch manufacturing and packaging (microthermoforming for medium volumes; injection molding for high volumes).

Key applications:

  • Febrile illness: Proof-of-principle at Inst. Pasteur, Senegal & Central Lab Khartoum, Sudan (panel: malaria, dengue, chikungunya, Zika, typhoid, pneumonia) (www.discognosis.eu)
  • Vector control (malaria and arbovirus vectors): Ongoing projects (www.dmc-malvec.eu, infravec2.eu)
  • Respiratory tract infections & resistances: ongoing projects (www.diagoras.eu)

Internet link:

Organization:
Hahn-Schickard, Germany

Contact:
Dr. Konstantinos Mitsakakis
Hahn-Schickard
Group Leader International Business Development
Konstantinos.Mitsakakis@Hahn-Schickard.de

Place in the Global Health Lab:
DT12

Photo 1 : The LabDisk and corresponding processing device. Source: “Hahn-Schickard, Bernd Müller Fotografie”
Photo 2 : Scale Up Pilot Line at Hahn-Schickard. Source: “Hahn-Schickard, Bernd Müller Fotografie”
Photo 3 : LabDisks produced at Hahn-Schickard’s Design & Foundry Service. Source: “Hahn-Schickard, Bernd Müller Fotografie”